San Francisco, CA – On the late night of Wednesday, July 23, 2025, a multi-vehicle collision on Interstate 280 resulted in at least one fatality, according to CHP Fatal.
The California Highway Patrol reports that the crash took place around 11:52 PM on southbound Interstate 280 near the transition road to State Route 1, just north of the Eastmoor Avenue and Pacifica exits.
Initial reports indicate that the incident involved as many as five vehicles, including a black sedan, a silver sedan, an orange Chevrolet pickup truck, a white Ford sedan, and a Toyota Prius. Multiple lanes were blocked following the collision, and emergency responders reported that one vehicle was partially wedged beneath another. The crash occurred along a heavily trafficked span of the highway near the entrance to the San Francisco city limits.
Emergency crews from multiple agencies, including the fire department and medical personnel, responded to the scene. One person, whose identity has not been confirmed, was declared deceased and was transported from the transition road to San Francisco General Hospital. CHP referred to the individual as “John Doe” pending official identification.
Several tow trucks were dispatched to clear the damaged vehicles from the scene, and the highway experienced partial closures for several hours overnight. A SigAlert was issued shortly after midnight and remained in effect until all lanes were reopened at approximately 2:25 AM on Thursday, July 24.
The California Highway Patrol San Francisco office is handling the investigation. The cause of the collision and the total number of injuries, if any, have not yet been determined. The incident remains under active investigation.
Wrongful Death Claims & Comparative Negligence
Determining fault in a collision can involve multiple factors, and under California’s Comparative Negligence rule, several parties can share partial responsibility. Should someone else be found even partly responsible for the death, the family may be able to file a Wrongful Death claim against the at-fault driver’s insurance. This can provide compensation to help cover medical bills, funeral expenses, and the loss of income to support the family of the deceased.
